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The human pathogen Mycobacterium tuberculosis has coevolved with humans and uses novel strategies for intracellular survival as well as for drug resistance. In this communication, we have compared the drug resistance of Mycobacterium marinum as well as the H37Ra, an avirulent form of the human pathogen M. tuberculosis against second-generation antibiotic capreomycin. Interestingly, M. marinum and its three mutants are naturally resistant to capreomycin, while the H37Ra showed susceptibility and also it showed surface expression for the TlyA protein since function of TlyA is necessary for susceptibility to capreomycin. It is postulated that the resistance to capreomycin can occur in wild-type strains through suppression of expression of TlyA, while the H37Ra is unable to do the same.

TlyA Expression is Necessary for Mycobacterial Susceptibility to Capreomycin: Wild-type Strains are Naturally Resistant