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Biomedical/clinical engineering departments (CED) with expertise in engineering and technology management have a vital role to play in determining the potential for implementation and cost-effectiveness of new medical technologies through technology assessment. It provides planned preventive maintenance and repair facility in a state of optimum operational efficiency along with conducts training and research in clinical engineering. For a successful design, the workflow should be kept in mind in terms of its functional needs that are related to space. The clinical engineering and maintenance unit may consist of functional areas dependent on the operational policy and service demand. Heating, ventilation and air-conditioning (HVAC), lighting and acoustic, electrical, fire planning should be done with deliberation and as per specification.   How to cite this article  Singh MM, Patnaik SK, Srivastva P, Satia HK, Singh M. Planning and Designing of Clinical Engineering Department in a Hospital. Int J Res Foundation Hosp Healthc Adm 2015;3(2):129-134.