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We present a case posted for CABG with double valve replacement (DVR) for triple-vessel coronary artery disease (CAD), rheumatic severe mitral regurgitation, and severe aortic stenosis. However, preprocedure echocardiography in the operation theater confirmed the diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) instead of valvular aortic stenosis, thereby altering the procedure performed to CABG, mitral valve replacement (MVR), and myectomy.   How to cite this article  Mandal B, Rana SS, Munirathinam GK, Ghotra SS. Role of Perioperative Echocardiography in the Diagnosis of Hypertrophic Cardiomyopathy: Decoding Special Problem in the Background of Commoners. J Perioper Echocardiogr 2017;5(1):27-30.