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Background: Detection of oral squamous cell carcinoma (OSCC) at an early stage would be a paramount for any suc­ cessful clinical treatment, and thus better prognosis. Serum proteomics, a minimally invasive procedure being simple, safe and accessible, is one of the methods that are used for detec­ tion of various biomarkers that could be of diagnostic and prog­ nostic importance for diseases including OSCC. The aim of this prospective study was to determine the role of serum albumin, globulin levels and albumin/globulin (A/G) ratio as a reliable diagnostic and prognostic biomarker in OSCC. Materials and methods: The study was conducted on 30 clini­ cally diagnosed OSCC patients and 10 normal healthy patients of the control group. Blood samples were collected from all patients under necessary precautions and processed further to obtain serum. Biopsies were obtained from OSCC patients and were histopathologically graded into well, moderate and poorly differentiated OSCC. Serum sample from both groups was evaluated and statistically analyzed for albumin, globulin and A/G ratio. Results: Serum albumin, globulin and A/G ratio levels did not show any statistically significant increase in OSCC patients as compared to the control group. However, A/G ratio decreased with the advancement of disease. Conclusion: The results obtained suggested that serum albumin, globulin and A/G ratio cannot be used as serum markers for diagnosis of OSCC. However, there have been studies suggesting significant increase in the levels, hence we empha­ size on the need for more studies with larger sample sizes to be conducted for determining the role.

Serum Albumin, Globulin and Albumin/Globulin Ratio in Oral Squamous Cell Carcinoma: A Prospective Study