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Screening for aneuploidies is a vital component of routine antenatal care. Conventional screening methods include biochemical screening and ultrasonography. Interpretation of these tests and further course of management can be enigmatic. Noninvasive prenatal test (NIPT) using cell-free fetal deoxyribonucleic acid (DNA) is an emerging screening method with accuracy close to the diagnostic invasive tests. We present a case of an elderly primigravida, conceived after years of infertility, in whom the first trimester combined screen was reported as intermediate risk and NIPT helped in reaching the diagnosis of fetal Down’s syndrome.

Contingency Screening using Noninvasive Prenatal Test for the Detection of Trisomy 21