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Objective: To compare the perinatal transmission rate, maternal and neonatal outcome among HIV positive women on triple drug antiretroviral therapy (ART) with women receiving antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT). Materials and methods: This prospective study recruited all HIV positive antenatal women who delivered at Postgraduate Institute of Medical Education and Research, Chandigarh from June 2010 to December 2011. The rate of HIV perinatal transmission was calculated in the two groups. The perinatal outcome was studied in the form of birth weight, gestation at delivery, mode of delivery, maternal morbidity and mortality. Results: The overall HIV transmission rate was 13.3% (10% in ART group and 15% in ARV group). A trend was seen toward a lower MTCT among women in ARV prophylaxis group who delivered by elective cesarean section (CS) as compared to vaginal delivery (7.7 vs 16.7%). Conclusion: The vertical transmission rate of HIV was lower among women receiving triple drug ART. The mode of delivery did not affect the transmission rate in this group.

journal of postgraduate medicine, education and research

Perinatal Transmission of HIV in Women Receiving Antiretroviral Prophylaxis/Therapy during Pregnancy with Zidovudine, Lamivudine, and Nevirapine: Experience at Tertiary Care Center in India