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Purpose: To demonstrate that UVA/riboflavin crosslinking (CXL) can cause corneal melting in some unpredictable cases. Materials and methods: We will present a case report of 25-year-old male patient referred for emergency keratoplasty which is due to corneal melting and perforation developed after uneventful CXL procedure for the treatment of keratoconus. Results: We performed uncomplicated penetrating keratoplasty of the left eye in our hospital. Conclusion: CXL is gradually becoming the standard treatment procedure for progressive keratoconus and the only major safety concerns associated with CXL are ocular surface damage and endothelial cell damage. This case has shown, however, that even if CXL seems to have been successful, there is still a risk of adverse outcomes. Our report suggests that further research is necessary regarding the safety of corneal collagen crosslinking in corneas with keratoconus.

Case of Corneal Perforation as a Complication after Uneventful CXL without Infection