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Giant cell lesions are characterised histologically by multinucleated giant cells in a background of ovoid to spindle-shaped mesenchymal cells. There is a major debate whether these lesions are separate entities or variants of the same disease. Our aim was to study the nature of multinucleated and mononuclear cells from peripheral giant cell granuloma (PGCG), and central giant cell granuloma (CGCG) and giant cell tumor (GCT) of long bones using immunohistochemistry evaluation and to determine whether there is a correlation between recurrence and the markers used.

the journal of contemporary dental practice

Immunohistochemical Comparison of p53, Ki-67, CD68, Vimentin, α-smooth Muscle Actin and Alpha-1-Antichymotrypsin in Oral Peripheral and Central Giant Cell Granuloma