English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are major health problems. Although both diseases follow asimilar course of disease progression from an early reversible fatty liver stage to severe necroinflammation with or without fibrosis andcirrhosis, the mechanisms of ALD and NAFLD are not well understood. This preliminary study was conducted to determine blood alcoholconcentration (BAC) and altered proteins and fatty acid ethyl esters (FAEEs, nonoxidative metabolites of ethanol) in the plasma of patientsdiagnosed with ALD or NAFLD. Differentially altered proteins were identified by two-dimensional gel electrophoresis and mass spectrometry,FAEEs by gas chromatography and BAC by an enzymatic method. Precursors of complement C3, complement C6 and serum amyloid A-4protein, and Ig gamma-3 chain C region were significantly decreased in ALD vs controls (group 1). Haptoglobin precursor was the onlyaltered protein (increased) in NAFLD vs controls (group 2). However, significantly increased levels of precursors of complements C3, C4-Band C6 and decreased levels of immunoglobulin J chain and Leucine-rich alpha-2 glycoprotein precursor were observed in NAFLD vs ALD(group 3). These results indicate potential of precursors of complements C3 and C6 and haptoglobin for the differential diagnosis of ALD andNAFLD. Although high BAC and plasma FAEEs levels in the ALD group appear to be associated with chronic alcohol abuse, biologicalsignificance of endogenous biosynthesis of FAEEs yet to be established. Therefore, a detailed proteomic and lipidomic study need to beconducted in larger cohorts to understand the etiopathogenesis of ALD and NAFLD.

Differentially Altered Plasma Proteins in Patients diagnosed with Alcoholic and Nonalcoholic Fatty Liver Disease