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Glioblastoma is one of the most common and most aggressive malignant primary tumors of the central nervous system which originates in astrocyte cells accounting for ~12 to 15% of all intracranial neoplasms. Its development to extracranial areas is very rare, occurring in <2% of patients. Very few cases (<200) of extracranial metastases have been reported so far. Despite advances in treatment of GBM, the prognosis is poor with an average survival time of about 14 months. Aim: The aim of the study is to present the spread of glioblastoma multiforme (GBM) to the extracranial area. Case report: A 29-year-old woman suffering from severe headaches revealed a history of brain surgery due to GBM in the temporal area done 5 months ago. Conclusion: With regard to this, extracranial metastasis of GBM is rare and the nature of the lesion is not well defined; therefore, the treatment for patients is not favorable and their survival is short (after metastasis). Since the molecular and genetic factors in metastatic GBM may have a key role, these markers can be used as future therapeutic goals. Clinical significance: In this study, we presented a 29-year-old woman with the spread of GBM to the maxillofacial area after GBM surgery 5 months ago.

Rapid Progression of Primary Glioblastoma to the Maxillofacial Area in a 29-year-old Woman