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Aim: This study aims to investigate the effect of a calcium phosphate-based desensitizer paste on reduction of dentin hypersensitivity (DH). Materials and methods: This crossover study was designed as randomized, double-blinded, and placebo-controlled trial. Teethmate AP paste (TAP), containing tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) dispersed in a glycerol/polyethylene glycol paste, was compared with placebo (PLA), a calcium phosphate-free analog paste. A total of 45 patients with one hypersensitive cervical lesion in each of two contralateral quadrants were allocated to the trial when baseline sensitivity (pretreatment sensitivity score, PRE) on air-blast (AB) stimulation and probe scratching (PS) measured on a visual analog scale (VAS; 0–10) was ≥6. Patients were recalled after 1 day, 1 week, and 1, 3, and 6 months. One-way analysis of variance (ANOVA), Tukey’s post hoc test, and pairwise comparisons between TAP and PLA were conducted at all time points (α < 0.05). Results: Both treatments reduced DH significantly during the 6-month course. Immediately after treatment (posttreatment sensitivity score, POST), TAP sensitivity on AB was reduced to 63%, after 6 months to 39% of the PRE score, and PS to 60 and 54% respectively. Application of PLA reduced AB sensitivity at POST and 6 months to 79 and 60%, and on PS stimulation to 79 and 67% respectively. At all time points, TAP and PLA were significantly different (p < 0.05). Conclusion: Teethmate AP paste is a biocompatible and effective desensitizing agent when used for the treatment of moderately severe DH. Clinical significance: Calcium phosphate-based desensitizers are one of the most effective desensitizing agents and are expected to play an important role in the treatment of DH. ORIGINAL RESEARCH 1,2Department of Conservative Dentistry and Endodontics, KLE Society’s Institute of Dental Sciences, Bengaluru, Karnataka India 3Department of Conservative Dentistry and Endodontics Vokkaligara Sangha Dental College and Hospital, Bengaluru Karnataka, India 4Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Aoba-ku, Sendai, Japan 5Division of Advanced Prosthetic Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry, Aoba-ku, Sendai, Japan Corresponding Author: Deepak Mehta, Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India Phone: +919845140082, e-mail: drdeemehta@gmail.com 10.5005/jp-journals-10015-1483

A Novel Desensitizer Paste containing Calcium Phosphate: Randomized, Placebo-controlled, Double-blinded and 6 Months Trial