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Objective: To evaluate the effect of tranexamic acid, an antifibrinolytic agent, in reduction of surgical hemorrhage during endoscopic nasalsurgery.Design: Comparative analysis of the use of tranexamic acid in 200 patients undergoing endoscopic nasal surgery and its demonstrablereduction of hemorrhage and improvement of visibility of operative field.Subjects: Around 200 patients with varied indications underwent endoscopic nasal surgery; 100 were given tranexamic acid perioperativelyand 100 did not receive tranexamic acid and were used as a control. Selection of patients was done on random basis. We used the followingparameters to measure intraoperative blood loss: Visibility of field of surgery, weight of blood swabs postoperatively and amount of bloodfrom suction machine.Result: Patient who received tranexamic acid showed reduction of blood loss amounting to 72.48% ( p < 0.05 ). This reduction was comparedwith results published by other authors using various kinds of anesthesia.Conclusions: Tranexamic acid is an antifibrinolytic agent which inhibits the action of plasmin. There is also reduction in blood level ofD-dimer. It is seen to significantly reduce intraoperative blood loss during endoscopic nasal surgery. Additionally, there seems to be noalteration of coagulation parameters or untoward systemic effects. The consequent improvement in surgical field visibility is of great benefitwhich is encouraging and should prompt further trials.

Short-term Use of Tranexamic Acid to Reduce Blood Loss in Endoscopic Nasal Surgeries