English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Ultrasound screening has advantages over maternal serum screening. These include confirmation of embryo viability, accurate assessmentof gestational age, early diagnosis of multiple pregnancies and identification of chorionicity, the detection of major structural abnormalities,major defects of the heart and great arteries, skeletal dysplasias and genetic syndrome and measurement of NT thickness in assessingthe risk for Downs syndrome. Nuchal translucency (NT) has emerged as the most sensitive ultrasound marker for detection of chromosomalanomalies in the first trimester. However, the use of ultrasound in routine screening still faces problems with reliability and quality control.Combination of maternal age, NT and first and biochemical second-trimester markers is known as the integrated test. A major goal ofscreening tests is to achieve high detection rate and low false-positive rate at a low cost. The integrated test best meets these criteria.It could achieve a detection rate of 85% for a false-positive rate of 1.2%. It has a much better positive predictive value and, therefore,fewer amniocentesis and fewer losses of normal fetuses. Only screen-positive cases could be taken for invasive testing.

Integrated Screening for Chromosomal Anomalies: Strategies in Developing Countries