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Drug allergy encompasses a spectrum of immunologically mediated hypersensitivity reaction with varying mechanisms and clinical presentation. Type of adverse drug reaction not only affects patient’s quality of life, but may also lead to delayed treatment, unnecessary investigations and even mortality. The most effective strategy for the management of drug allergy is the avoidance or discontinuation of the offending drug. When available, alternative medications with unrelated chemical structures should be substituted. Patients who presents with history of allergy to local anesthetics are common in dental practices. In the present report, retrospective documented history of allergy to local anesthetics (lidocaine) in two patients (50 years/female, 35 years/male) were evaluated critically and needful dental treatment procedures were carried out using antihistamines pheniramine maleate: 22.75 mg/ml; DPH HCl: 1%) as local anesthetic agents. In both the cases, antihistamines proved to be benefi cial, effective, devoid of complications. In conclusion, use of antihistaminic drugs in patients with documented history of allergy could be an alternative drug of choice having local anesthetic properties for minor dental treatment procedures in routine dental practice.

international journal of head and neck surgery

Antihistamines in Clinical Dentistry offering a Choice for Second Possibility in Reported Cases of Allergy to Local Anesthetics: Report of Two Cases and Literature Review