English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of this study is to illustrate the relationship between α-Galatosylceramide (α-GalCer) dose and α-GalCer induced anergy of immune system in vivo. α-GalCer, a glycolipid and a widely studied immune modulator extracted from a marine sponge, shows its effect in vivo via presentation on CD1d molecule, MHC I like molecule bound glycolipid antigens, to NKT cells, a lymphocyte has both TCR and NK1.1, marker of T cells and NK cells respectively. The contradictory reports about α-GalCer are focused on two opposite axes of immune system: cancer and autoimmunity, failure and exaggeration of Th1 type immune response, respectively. In this study, the relation between the α-GalCer dose and the anergy was considered to clarify this dilemma. The groups of BALB/c mice were injected with various titer of α-GalCer intravenous way repeatedly and serum level of IFN-γ was measured with mouse IFN-γ ELISA. The Dramatic difference was found between groups after 2nd application of α-GalCer: Low dose α-GalCer boosted IFN-γ; however, high dose, usual dose cited in literature, failed to induce IFN-γ production. Besides, low concentrations of _-GalCer succeeded considerable amount of IFN-γ in the serum after priming. This results show that minute level of α-GalCer can be recognized by NKT cells, and repeated in vivo application of low dose α-GalCer can improve Th1 capabilities of the immune system.

Intravenous Repeated Application of Low Dose α-Galatosylceramide Boosts IFN-γ Production in BALB/c Mice