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The ‘Testosterone Trials’ (TTT) are an interlinked and coordinated series of seven US National Institutes of Health (NIH)-sponsored, double-blinded, placebocontrolled studies examining the potential benefits of testosterone therapy in a hyper-selected cohort of older men. TTT aimed to evaluate the impact of testosterone therapy on symptoms commonly associated with male ageing and also postulated to relate to testosterone deficiency, but were not powered to detect adverse outcomes. Findings from the three lead studies, focusing on vitality, sexual and physical function, were recently published.

Have the Testosterone Trials Demonstrated the Effectiveness of Testosterone Therapy in Older Men without Classical Hypogonadism?