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Wurster granulation with external product classification can be used for stable continuous coating or layering processes. It has been ascertained from recent population balance simulations that the ratio of the spray rate to the nuclei feed rate can be used to control the thickness of the sprayed product layer. However, thermal conditions are not considered by population balances regarding the particle size as distributed property. For this reason, heat and mass transfer is investigated in the present contribution by modelling of several subprocesses. The results can be used to discuss the cause of fluidized bed destabilization due to over-wetting.

Heat and mass transfer modelling of continuous Wurster-spray-granulation with external product classification