English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background and Aims: The significance of circulating galectin-3 in esophageal cancer has not yet been elucidated. The aim of this study was to identify the relationships between circulating galectin-3 and angiogenetic, nutritional, and inflammatory factors in patients with stage IV esophageal cancer. Materials and Methods: We investigated the relationships between the level of circulating galectin-3 and angiogenetic factors, such as interleukin (IL)-6, vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor (G-CSF), and soluble intercellular adhesion molecule-1 (sICAM-1), and nutritional and inflammatory indicators in 11 patients with stage IV esophageal cancer. Results: The concentration of galectin-3 in patients with stage IV esophageal cancer was significantly higher than in healthy volunteers. The amount of circulating galectin-3 correlated with the amount of serum IL-6 (r = 0.636, P < 0.05), VEGF (r = 0.721, P < 0.05), sICAM-1 (r = 0.745, P < 0.01), and C-reactive protein (r = 0.786, P < 0.05), as well as the lymphocyte count (r = −0.718, P < 0.05), and the neutrophil / lymphocyte ratio (r = 0.718, P < 0.05). Conclusions: Galectin-3 may play a key role in progression of tumors by increasing the production of angiogenetic factors, leading to malnutrition by persistent systemic inflammation.

Circulating galectin-3 correlates with angiogenetic factors and indicators of systemic inflammation in patients with stage IV esophageal cancer