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Purpose: A feasibility study was conducted to investigate whether synchronized intra-aortic chemotherapy (SIAC) could be a safe method, and improve quality of life of far advanced gastric cancer patients with tumor-related symptoms. Patients and Methods: Sixty-seven patients disordered their performance status with stage IV or recurrent gastric cancer localized to the abdominal cavity were entered in the study. SIAC regimen consisted of bolus intra-aortic injection (IA) of cisplatin 6 mg/m/body and methotrexate 6 mg/m/body per day on days 1 to 5 in the morning, followed by continuous IA of 5-fluorouracil 150 mg/m/body/day for 5 days, and systemic infusion of l-leucovorin 15 mg/m/body/day on days 2 to 6 at 8 PM, repeated every 3 weeks for the first three courses and every 1-3 months after the fourth course. Results: The response rate was 61% (CR 2, PR 37). The tumor control rate (CR+PR+NC) was 89%. Performance status were improved in 51% of the patients. The incidences of side effects of grade 3 or more was anorexia 8.9%, leucopenia 4.5%, and nausea 3.0%. Conclusion: These data suggest that SIAC regimen is safe and effective for response rate and performance status in patients with stage IV advanced gastric cancer, localized in the abdominal cavity.

Feasibility Study of Synchronized Intra-aortic Chemotherapy for Stage IV and Recurrent Gastric Cancer Localized in the Abdominal Cavity