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Various significant levels of lipid peroxides were observed in patients with different liver diseases. The increased values of lipid peroxides might be correlated with the modifications in pathological way of bilirubin, glutamate, pyruvate-transaminase, glutathione, triglycerides, and chemiluminescence. This correlation was observed in the acute hepatic insufficiency such as acute viral hepatitis, hepatic coma, ethylic cyrrhosis. The increase of lipid peroxides in the serum of these patients is related to tissue destructions, cellular membrane lysis, and subsequent release of polyunsaturated fatty acids. The determination of lipid peroxides in liver deficiency might indicate an irreversible liver damage and the failure of the antioxidant systems to exert a protective role.

HIGH SERUM LIPID PEROXIDES AND THEIR SIGNIFICANCE IN PATIENTS WITH LIVER DEFICIENCY