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The Bradford Hill Criteria are widely used by the scientific community to establish causal inference from observational data. Since their original publication in 1965, these criteria have been updated to incorporate modern molecular methods and data integration to strengthen the determination of causality. These nine criteria can be definitively applied to the association between Adverse Childhood Experiences (ACEs) and poor health outcomes.

The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health