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In the present study the Suitable analytical methods were developed for the drug using UV – visible spectrophotometer. From the Preformulation study and thermal analysis (DSC), the interference was verified and found that the drug did not interfere with the excipient use.Core tablet was successfully prepared by wet granulation using Polyethylene oxide WSR N80, Mannitol 25C, silicon dioxide, magnesium stearate, Polyethylene WSR 303, sodium chloride, hydroxypropyl methylcellulose (HPMC E5), Iron oxide red. Isopropyl cellulose was found to be suitable granulating fluid for binder.Formulation of the drug coating was optimized by using 22 factorial design of experiment.The coated tablets were evaluated for various physicochemical parameter. About  79 to 95% of drug was released from the formulation A-E in 24 hr in 6.8 phosphate buffer.The in vitro drug release data were plotted in zero order kinetics and optimized batch were evaluated on the basis of regression coefficient.The in-vitro drug release from the optimized formulation in the dissertation was directly proportional to the concentration of plasticizer and concentration of cellulose acetate.The manufacturing procedure was standardized and reproducible

Osmotic release tablets formulation and evaluationof ace inhibitor molecule