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Just as Peter asked Jesus in the New Testament about two thousand years ago, Domine, quo vadis? (i.e, to be crucified again?), we may ask ourselves today within the context of medicina ex testimoniis [1] where we are a quarter century or so since the birth of evidence-based medicine. Where do we go from here and where we will probably go? Thirteen years ago, we poseda similar question and concluded then that the evidence-based medicine (EBM) glass remains half-full and half empty. [2] Use of ‘evidence’ in logic and critical thinking still requires clarification.

Quo Vadismedicina Ex Testimoniis? A Quarter Century after its Inception, Where is Evidence-Based Medicine Now? More Questions than Answers