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The use of central venous catheter (CVC) is associated with risk of catheter-related infection (CRI). They have a huge impact on healthcare costs. One of the prevention strategies of CRI is the administration of non-antibiotic lock solutions such as taurolidine. Taurolidine has been proposed as a lock therapy in CVC because of its antimicrobial effect against a broad range of microrganisms. Some authors suggest a beneficial role of taurolidine lock solution application not only for prevention of CRI but for CRI therapy too. In this paper we report six cases of patient undergoing TPN with CRI treated with taurolidine 1.35 % citrate 4% (TC), implanted in Department of Pain Therapy Vascular Access Device Ambulatory, (Monaldi Hospital, Naples Italy). Patients were in Total Parenteral Nutrition (TPN) and received central (CBC) and peripheral blood culture (PBC), clinical evalutation, white blood cell (WBC) count. Patients with positive blood culture received TC every 48 hours throughout vascular access. Parenteral nutrition was suspended only during the day of TC infusion. The drug was administered until the patients didn’t show no fever. In our experience, TC eradicated CRI in all six patients in a six-days therapy, interrupting the TPN only for three days. No side effects occurred. The efficacy of TC in this series of case reports has made possible to resolve all CRI with simple outpatient treatments and therefore could be a further task in the management of infective TPN complication.

Catheter-Related Infection (CRI) Treatment with Taurolidine - Citrate Lock Solution in Patients Undergoing Total Parenteral Nutrition