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Sapindus saponaria L. has revealed a number of properties of this plant which includes antioxidant, hepatoprotective, antiinflammatory, anticancer, anxiolytic, fungicidal, spermicidal activity. The present study investigated the anti-cancer activity of Sapindus saponaria L. pericarp extract (SSFE) on hepato carcinoma cell lines. The extract and fractions significantly inhibited cell the viability in a time and concentration dependent manner in both the carcinoma cells. Morphological study showed several signs of apoptosis like chromatin condensation, nuclear fragmentation and formation of apoptotic bodies and degraded DNA bands in both the treated hepatoma cells than control. Treated cells exerted significant MMP shift in the mitochondrial transmembrane potential activity involving the release of cytochrome c into the cytosol. The cell cycle phase arrest was observed in the G0/G1 phase change in the EFESS treated cells. These findings suggest that extracts possess cytotoxic and apoptosis activity against both the hepatocellular carcinoma cells. Further mechanistic studies are under process to determine the different pathways attributing to apoptosis.

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells