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Plant is an important medicinal source, and plays a key role in world health. Limonia acidissima have been known to be an important potential source of therapeutics and curative aids. In previous studies it has been reported Limonia acidissima showed antibacterial activity, antidiarrhoeal activity, anticancer activity and wound healing potential. There are no reports on hepatoprotective activity of this plant. The present study was planned to scientifically investigate the hepatoprotective activity of ethanolic extract of Limonia acidissima against paracetamol (PCM) induced hepatotoxicity model. The animals were grouped into five groups of six animals each. Except the normal group all the other groups received PCM at a dose of 1.5 ml/kg b.w orally for 14 days. Normal groups received distilled water orally. The standard group received silymarin 100 mg/kg orally. Test groups received EELA 200 mg/kg and 400mg/kg b.w orally. On the 14th day, blood samples were collected and serum was separated which is in turn used to analyze liver function tests such as SGOT, SGPT, ALP, Total bilirubin, Total cholesterol, Total protein levels. The results thus obtained showed significant improvement in these parameters. Thus, concluding that the ethanolic extract of Limonia acidissima possesses hepatoprotective activity.

Evaluation of Hepatoprotective Activity of the Ethanolic Extract of Limonia acidisiima against Paracetamol induced Hepatotoxicity in Experimental Rats