English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Preeclampsia (PE) is diagnosed after 20 weeks of gestation. This multisystem disorder affects 2-7% of pregnant women. Preeclampsia (PE) is a serious complication of pregnancy and one of the main causes of maternal and neonatal mortality and morbidity in the world. The inadequate placentation process results in a change in anti-angiogenic factors levels, such as placental protein 13 and soluble fms-like tyrosine kinase 1 (sFlt-1). Objectives: To investigate the correlation between urinary placental protein (placental protein 13) and soluble fms like tyrosine kinase-1(sFLT-1) in preeclamptic women in their third trimester of pregnancy. Methods:  A case-control study was carried out from August 2018 till January   2019. Urine samples were collected from pregnant women at   Al-Elweyia Hospital, Al-Hakeem Hospital, and Al- Imamain alkadhimain Medical City. The patient groups include fifty women with preeclampsia in the third trimester (25 mild and 25 severe). Fifty healthy pregnant women (at their third trimester of pregnancy) were studied as a control group. Results: The mean urinary placental protein 13 levels were decreased in women with preeclampsia significantly (P? 0.05) (mild and severe) compared with healthy women (43.44± 4.914 pg/ml, 33.34± 1.863 pg/ml, and 51.84 ±2.60 pg/ml ) respectively. Also, urinary SFLT-1 concentrations were decreased non-significantly (P > 0.05)  in women with preeclampsia (mild and severe)  compared with healthy women (5.71±0.414 ng/ml, 5.31± 0.38 ng/ml and 6.01 ± 0.282 ng/ml) respectively.   Conclusion:  Urinary placental protein and soluble fms- like tyrosine kinase-1 levels in the third trimester of pregnancy were significantly correlated with the severity of preeclampsia, and urinary levels of placental protein  13 were found to be decreased significantly in patients with preeclampsia than in healthy pregnant women in the 3rd trimester of pregnancy.

association between urinary placental protein 13 and soluble fms-like tyrosine kinase-1 in preeclamptic women in the third trimester of pregnancy