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This study aims to determine the effectiveness of Problem Based Learning (PBL)-based e-module. The method used was a quasi-experimental with a Posttest Only Control Design. The pilot sample in this study were the students of the Biology Study Program, Universitas NegeriPadang (UNP) in 2019 academic year chosen by using a purposive sampling technique. The instruments used in this study were the lecturer interview questionnaires, student needs analysis questionnaires, validity and practicality questionnaires and evaluation questions based on critical thinking indicators. The results of the analysis of evaluation questions showed that the mean scores of critical thinking skills of the experimental class students were higher than the control class. The mean score of the experimental class was 76.89 while the control class was 65.11. The result of critical thinking t test shows that t count (0.000) &lt; from (0.05). Thus, it indicates that the e-module on PBL-based classical genetic material is effective for improving the students' critical thinking skills.

The Effectiveness of Problem Based Learning (PBL) Based E-Module on the Classic Genetic Materials to Improve the Student's Critical Thinking Skills