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Endogenous adult-derived Totipotent Stem Cells (TSCs) and tissue-resident exosomes are major players in the field of regenerative medicine. TSCs provide the undifferentiated building blocks for tissue repair, while exosomes provide the directions on how these building blocks should be used to accomplish this feat, i.e., restoration of fully functional tissue. Both TSCs and exosomes have been extensively characterized with respect to composition and function. While they have similar characteristics in four categories, they differ with respect to each other in a myriad of other categories. The following is criteria used by this lab to distinguish telomerase-positive totipotent stem cells from bioactive factor-containing exosomes.

Criteria to Distinguish Endogenous Telomerase-Positive Totipotent Stem Cells from Exosomes as Major Players in Regenerative Medicine