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Epidermolysis Bullosa (EB) is a rare, heritable skin disease that encompasses several subtypes, which vary widely in presentation and prognosis. One subtype, Recessive Dystrophic Epidermolysis Bullosa (RDEB), is especially rare and debilitating. It occurs due to a mutation in the COL7A1 gene that encodes for type VII collagen leading to chronic, diffuse skin and mucosal blistering. Given the rarity of the disease, guidelines for treatment of pregnant patients with RDEB do not currently exist. This case describes the pregnancy course of a 21-year-old female with RDEB. She conceived vaginally and had a term normal vaginal delivery complicated by postpartum hemorrhage. She declined genetic testing of her infant, but he was born with no cutaneous signs of EB. Key aspects of care were a multidisciplinary evaluation with maternal-fetal medicine assistance and close follow-up. A discussion of several interesting aspects of the case follows the report. * This case report has been approved per Central Michigan University’s guidelines and written consent for publication was obtained from the patient due to the rarity of her condition.

Managing pregnancy in a patient with Recessive Dystrophic Epidermolysis Bullosa: A case report