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Background: One of the most serious and contagious disease, associated with considerable effects on quality of life and death rates is bacterial meningitis. Urgent diagnosis, treatment, and prevention are required in 10 to 20% of survivors with advancing debilitating neurologic complications. In developing countries the prevalence of meningitis is usually high in low-socioeconomic status. Objective: To determine the Diagnostic Accuracy of Post Contrast FLAIR MR imaging for suspected meningitis in pediatric patients taking Lumbar Puncture as Gold Standard. Methods: The Study was done at Department of Radiology, in which calculated sample size was 100 children with suspected meningitis aged 2 – 12 years of age. MRI brain was performed from vertex to the base of skull on PhilipsTM Achieva 1.5 tesla (T) MR System. Following MRI exam, CSF was collected via LP of each patient. The statistical analysis was done using SPSS package version 19.0. Results: Post contrast FLAIR MRI findings were positive in 48 (48 %) while negative in 52 (52 %) while lumbar puncture revealed positive findings in 51 (51 %) while negative in 49 (49 %). Sensitivity of the post contrast FLAIR MRI was 78.43 % while specificity was 83.67 %, diagnostic accuracy was 81.00 %. Conclusion: The most authentic, secure and potent diagnostic tool for the detection of meningitis among suspected children is post contrast FLAIR magnetic resonance imaging. Our study represents that post-contrast FLAIR MRI has high sensitivity, specificity and detecting accuracy in diagnosis of meningitis among influenced population.

open access journal of biogeneric science and research

Diagnostic Accuracy of Post Contrast Magnetic Resonance Imaging for Meningitis Taking Lumbar Puncture as Gold Standard. Experience at Nishtar Hospital-Multan