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Please cite this article as: Ishrath A et al., Formulation Development and Characterization of Diltiazem Pulsin Cap for Pulsatile Drug Delivery . American Journal of PharmTech Research 2019. Formulation Development and Characterization of Diltiazem Pulsin Cap for Pulsatile Drug Delivery Alisha Ishrath, Venkataratnam Devadas, Mohammed Mazher Ahmed 1.Department of Pharmaceutics, MAK College of Pharmacy, Hyderabad, Telangana, India 2.Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga, Karnataka, India ABSTRACT The aim of this work is to develop modified drug release by using Pulsin Cap technique with Diltiazem as model drug. From the above experimental results, it can be concluded that, Formulated granules gave satisfactory results for various micromeritic properties, dissolution and drug content. Formulated Pulsin Cap gave satisfactory results for various physicochemical parameters like weight variation. HPMC, Ethyl cellulose has predominant effect on the lag time, while also shows significant effect on drug release. Diltiazem Pulsin Cap shows a delayed release pattern. Among all the Diltiazem granules formulations F5 was selected based on drug release within a given period of time. In-vitro release rate studies showed that the PF5 was optimized based on less amount of drug release during lag time. Formulations PF5 found to be stable at 40 C and 75% RH for a period of 3 months. FT-IR studies revealed that there was no interaction between Diltiazem and the polymers.