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The estimation of Piperaquinen tetraphosphate and Dihydroartemisinin was done by RP-HPLC. The Phosphate buffer was pH 4.6 and the mobile phase was optimized which consists of MEOH: Phosphate buffer mixed in the ratio of 70:30 % v/ v. A Symmetry C18 (4.6 x 150mm, 5m, Make X Terra) column used as stationary phase. The detection was carried out using UV detector at 273 nm. The solutions were chromatographed at a constant flow rate of 1.0 ml/min. the linearity range of Piperaquinen tetraphosphate and Di hydro artemisinin were found to be from 25-125 g/ml. Linear regression coefficient was not more than 0.999.The values of % RSD are less than 2% indicating accuracy and precision of the method. The percentage recovery varies from 97-102% of Piperaquinen tetraphosphate and Di hydro artemisinin LOD and LOQ was found to be within limit. The proposed method is precise, simple and accurate to determine the amount of Piperaquinen tetraphosphate and Di hydro artemisinin in formulation. High percentage of recovery shows that the method is free from the interference of excipients used in the formulation. So the method can be useful in the routine quality control of these drugs.

Analytical Method Development and Validation of Piperaquine Tetraphosphate and Dihydroartemisinin In Combine Dosage Forms