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In in-vivo experiments, one of the fastest killers of metabolic processes is prolonged accumulation of free radicals, which are often accomplices of lipid peroxidation reactions. In this wise, though numerous studies have advocated its managements with anti-oxidants, research on antioxidants from herbal source remain inconclusive. Thus, current study determined the anti-antioxidant and lipid lowering tendencies of methanol leaf extract of Dennettia tripetala on alloxan induced diabetic mice. Sixty five (65) mice were procured and randomly assigned into thirteen (13) groups of five mice each. Following period of acclimatization (2 weeks), animals were fed with various treatment as follows; Group 1 (normal control), group 2 (diabetic control), group 3 (received 5 mg/kg of Glibenclamide, a known anti-diabetic agent) and groups 4 -13 were given 250 and 500 mg/kg doses of Methanol Extract [ME], N-Hexane Fraction [NH], Ethyl Acetate Fraction [EAF], Butanol [BF] and Water [WF] Fractions respectively. At the end of six (6) weeks treatment period, animals were subjected to overnight fast, with Fasting blood glucose (FBG) levels obtained by means of a glucometer, serum lipid profile levels were assayed (using a spectrophotometer) after obtaining blood samples by cardiac puncture. In the end, obtained data were subjected to statistical comparisons of mean differences, using the one way analysis of variance (ANOVA). Study observed a statistically significant decrease (p < 0.05) in FBG levels of extract treated group [ME] within 10 hours of acute treatment and 14 days short term treatment. Also, Administration of various treatments evoked a significant decrease (p < 0.05) in serum levels of total cholesterol, triglyceride and low density lipoproteins, with a preponderant significant elevation (p < 0.05) of high density lipoprotein (HDL-cholesterol) levels when compared with diabetic control.

ALTERATIONS IN ANTI-OXIDANT AND SERUM LIPID PROFILE IN ADMINISTRATION OF METHANOL EXTRACT OF DENNETTIA TRIPETALA ON DIABETIC MICE