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Background: A wide variety of medication, from vitamins to analgesics and anti-inflammatory drugs, can be purchased by users without a medical prescription. These are referred to as Oral Non-Prescription Drugs (ONPD). While this may empower patients to treat themselves, when used irrationally these medications can have a negative health impact. Previous research on higher education students, particularly healthcare students, has demonstrated that they might be a high-risk population for irrationally use of ONPD. In 2004, the World Health Organisation issued specific guidelines to address research in this area. However, recent investigations still indicate that irrational use of medication occurs among this population. Therefore, the current thesis will be guided by the WHO framework in an attempt to develop a strategy to address this problem.  Aim: The aim of this thesis is to determine the prevalence of irrational use of medication sold without a prescription in UAE to university students and to identify the reasons for this behaviour. A secondary aim of this investigation is to develop, implement and evaluate the effectiveness of an educational intervention to improve knowledge and awareness of, as well as attitudes and practice towards, rational use of ONPD medication by university students in UAE. To reach the aims of the study, a health behavioural model was used together with qualitative and quantitative methods.  Methodology Study One: The aim of this study was to determine the prevalence and risk factors of four types of irrational use (incautious use, inappropriate use, use of antibiotics without prescription and polypharmacy) of ONPD among undergraduate students in UAE. This study used a cross-sectional design employing a randomised sampling technique (n=2875).  Statistical analysis was used to analyse this data. Results obtained from this study indicated that 85.9% of students used ONPD, with 38.6% using antibiotics without a prescription. Based on WHO risk assessment criteria, this behaviour was found to the most severe form of irrational use. Additional findings indicated that female participants were 34% less likely to be incautious users (OR =0.344, 95% CI: 0. 244-0.486, p≤0.001), which set males at a higher risk of engaging in this behaviour. Not verifying the expiration date also increased the likelihood of being an incautious user by as much as 51%. Seeking drug information from health care professionals was found to be a protective factor against incautious ONPD use (OR =0. 798, 95% CI: 0.540-0.967, p967, p≤0.05). At the same time, not seeking information on cautious use of ONPD either from medical books or the internet was associated with a higher risk of incautious use (OR = 1.914, 95% CI: 1.353-2.708, p≤0.001). Being a healthcare student significantly increased the odds of being an incautious user of ONPD (OR = 1.561, 95% CI: 1.103-2.208, p≤0.05). Using antibiotics without a prescription was reported among 35.9% of the sample, with no statistically significant difference being observed between healthcare and non-healthcare students.  Study Two: Based on the WHO Severity Rating Matrix, the use of antibiotics without prescription was found to be the most significant risk for personal and population health. Therefore, the aim of this study was to further explore the reasons for use of antibiotics without prescription among healthcare university students. This study used a qualitative design employing an interview method and a purposive sample selection technique (n=15) which included only the population of students who used antibiotics without a prescription. Thematic analysis was used to analyse the data. Five main themes emerged from this study: knowledge, awareness, attitude, views, and perceptions, as well as possible strategies to decrease their misuse of antibiotics.  Study Three: The aim of this study was to develop and test an intervention for reducing the use of antibiotics without prescription based on the findings of study 1 and 2. The intervention was carried out for 14 weeks. Each session was delivered on a weekly basis and comprised of a 15 minutes PowerPoint presentation followed by 10 minutes of discussion. A quasi-experimental design with purposive sampling was used in which participants (n=140) were assessed at baseline for knowledge, awareness, attitude, and practice of using antibiotics without prescription. Results obtained through comparing baseline measures with post-intervention measures demonstrated a statistically significant (p&lt;0.05) improvement in reducing the use of antibiotic without prescription among the sample. Moderate improvements were also noted in knowledge, attitude, and awareness of antibiotic use.  Conclusion: This thesis has demonstrated that the prevalence of ONPD is high among university students in the UAE. This is particularly significant as this increased prevalence occurs concomitantly with irrational use. The most significant risk was related to using antibiotics without prescription. Although the intervention to change this behaviour was successful, other issues such as access to health care and lack of time to see medical practitioners may still promote the use of antibiotics without prescription. Recommendations underlined in this investigation include educating pharmacists to provide information to ONPD buyers.

Trends and practices in the use of non-prescription drugs among university students in the United Arab Emirates