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The increased presence of potentially toxic microalgae in the Mediterranean  area is a matter of great concern. Since the end of the last century, microalgae  of the genus Ostreopsis have been detected more and more frequently in the Italian  coastal waters. The presence of Ostreopsis spp. has been accompanied by the presence  of previously undetected marine biotoxins (palytoxins) into the ecosystem with the  increased possibility of human exposure. In response to the urgent need for toxicity  characterization of palytoxin and its congeners, an integrated study encompassing both  in vitro and in vivo methods was performed.

Sanitary problems related to the presence of Ostreopsis spp. in the Mediterranean Sea: a multidisciplinary scientific approach