The new genomic patient
Author(s) -
Christoph RehmannSutter
Publication year - 2015
Publication title -
schweizerische medizinische wochenschrift
Language(s) - English
Resource type - Journals
ISSN - 0036-7672
DOI - 10.4414/smw.2015.14089
Subject(s) - epigenome , genome , interactome , metabolome , computational biology , genetics , medicine , biology , bioinformatics , gene , dna methylation , gene expression , metabolomics
Each genome, epigenome, metabolome, microbiome, etc. is, as we learn, an interactome. In the philosopher’s imagination, the genome has lost its supremacy and at the same turn won in significance by acknowledging its interrelatedness with those other parts and processes in the cell it once was thought to dominate. Dead is the "genetic programme" model of the genome. Long live the genome as an intricate information resource that successfully interacts with other components and processes of the cell and is used by the cell (rather than controlling it) in sometimes unforeseen and complicated ways, as they have emerged during evolution. In this present time, genetics has become even more
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