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We report an HIV-HCV-HSV-2-coinfected man, who infected all of five sequential female sexual partners within seven years. HIV-RNA in semen was unusually high and exceeded that in plasma by one log10. Screening for sexually transmitted diseases remained negative with the exception of HSV-2-seropositivity. Recurrent asymptomatic genital herpes might explain the patient's increased HIV-RNA shedding in semen.

Unusually high HIV infectiousness in an HIV-, HCV- and HSV-2-coinfected heterosexual man