Open AccessCYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia
Author(s) -
Mehmet Taşpınar,
Sena Aydos,
Omer Comez,
Atilla Halil Elhan,
Halil Gürhan Karabulut,
Asuman Sunguroğlu
Publication year - 2008
Publication title -
swiss medical weekly
Language(s) - English
Resource type - Journals
eISSN - 1424-7860
pISSN - 1424-3997
DOI - 10.4414/smw.2008.12036
Subject(s) - genotype , allele , myeloid leukemia , medicine , allele frequency , gene , glutathione s transferase , null allele , genetic predisposition , myeloid , genetics , immunology , glutathione , biology , enzyme , biochemistry
Associations between polymorphisms for genes encoding enzymes involved in biotransformation of xenobiotics and susceptibility to several cancers have been shown in several studies. The aim of the present study is to investigate the influence of cytochromes P450 (CYP450) 1A1*2C and Glutathione S-transferases (GSTs) (T1 and M1) gene polymorphisms in susceptibility to chronic myeloid leukaemia (CML).
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