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Microextraction by packed sorbent (MEPS) is a new sample preparation technique developed in 2004. Actually, MEPS is a miniaturization of conventional solid phase extraction (SPE) packed bed devices from mililitre bed volumes to microlitre volumes. The key factor in MEPS is that the volume of solvent used to elute the analytes from the extraction process is of a suitable order of magnitude to be injected directly on-line into Liquid Chromatography, Gas Chromatography or Capillary Electrophoresis systems, without any modification of the instrument. This review focuses on MEPS theory and applications. MEPS procedure with different steps (sample preparation, analytes pre-concentration, sorbent washing, and analytes elution) is discussed for biological samples. A short overview of recent and successful applications of MEPS for determination of drugs and their metabolites in different biological matrices (plasma, urine, blood, hair) for therapeutic drug monitoring, doping inspection, biomarkers analysis, and forensic toxicology are also summarized.

Microextração em sorvente empacotado (MEPS) para a determinação de fármacos em fluidos biológicos