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espanolLa destruccion periodontal resulta de la interaccion entre la placa bacteriana y la respuesta inflamatoria inducida por mediadores que incluyen enzimas del huesped, citoquinas, y metabolitos del acido araquidonico (AA) tales como las prostaglandinas (PGs). Las PGs participan en la regulacion de diversas funciones celulares bajo condiciones fisiologicas y patologicas. La ciclooxigenasa (COX) proporciona la conversion de AA a PGs en tres formas funcionalmente distintas: COX-1, COX-2 y COX-3. COX-2, se induce despues de estimular una variedad de citoquinas inflamatorias, factores de crecimiento y lipopolisacaridos. Expresiones elevadas de COX-2 en periodontitis incrementan los niveles de PGs E2, considerados como los mayores mediadores de la destruccion tisular periodontal. Los antiinflamatorios no esteroides (AINES) inhiben la elaboracion de productos COX y pueden atenuar el avance de la perdida osea, convirtiendose en una alternativa terapeutica para el manejo de la periodontitis. EnglishPeriodontal tissue destruction occurs as a result of the interaction between dental plaque bacteria and the immunoinflamatory response induced by mediators like host enzymes, cytokines, and arachidonic acid metabolites such as prostaglandins (PGs). PGs play a role in the regulation of diverse cellular functions under physiological and pathological conditions. The ciclooxigenase (COX) enzyme providing the conversion of AA to PGs exists in two functionally distinct COX isoforms: COX-1 and COX-2. COX-2. The COX-2, is induced after stimulation by a variety of inflammatory cytokines, growth factors, and lipopolysaccarides. Higher expressions of COX-2 in periodontitis results in increases of the levels of prostaglandin E2 which are major mediators of periodontal tissue destruction. Non-steroidal anti-inflammatory drugs inhibit the production of COX products and can attenuate the progression of periodontal bone loss, become a therapeutic alternative for the management of periodontitis.

Antiinflamatorios no esteroides como terapia adjunta al raspado y alisado radicular en periodontitis