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espanolIntroduccion: los pacientes con dolor irruptivo oncologico (BTPc) experimentan un deterioro de las actividades de la vida diaria y de la calidad de vida. Tanto la funcion como la satisfaccion con el tratamiento pueden afectar a las capacidades de los pacientes para utilizar farmacos e impactar en sus respuestas a los mismos. Objetivo: este analisis exploratorio examina la relacion entre el estado funcional y la satisfaccion con la capacidad de usar el aerosol nasal de pectina de fentanilo (FPNS) para BTPc. Metodos: se analizaron datos de satisfaccion del tratamiento de un estudio multicentrico, abierto, a largo plazo usando FPNS para el tratamiento del BTPc en pacientes con Eastern Cooperative Oncology Group (ECOG) grado ≤ 2. Fueron evaluados la satisfaccion con la facilidad de uso, comodidad y fiabilidad de FPNS en escalas tres preguntas y cuatro puntos (1 = nada satisfecho, 2 = no satisfecho o insatisfecho, 3 = satisfecho, 4 = muy satisfecho) al final de 1, 4, 8 y 12 semanas. Para cada dominio, el porcentaje de pacientes que informaron estar "satisfechos o muy satisfechos" (puntuacion de 3 o 4) con FPNS se analizo basado en el grado ECOG. Resultados: en general, el 90 % de los pacientes con ECOG 0-2 dijo haber estado satisfecho o muy satisfecho con la FPNS en los tres dominios. Diferencias en la satisfaccion del paciente con FPNS por grado ECOG fueron clinicamente pequenas pero estadisticamente significativas (facilidad de uso: p = 0,0022, conveniencia: p = 0,0057 y fiabilidad: p = 0,0012). Conclusion: el dispositivo FPNS fue bien aceptado independientemente del grado ECOG (0-2). Estadisticamente, los pacientes con status de rendimiento superior (grados menores ECOG) informaron mayores puntuaciones de satisfaccion, aunque el tamano del efecto fue pequeno. Los resultados demuestran que el dispositivo FPNS proporciona un alto nivel de usabilidad independientemente del estado funcional, y que es probable que promover el uso y por lo tanto la probabilidad de exito en el control de BTPc. EnglishBackground: Patients with breakthrough pain in cancer (BTPc) experience impaired activities of daily living and quality of life. Both function and satisfaction with treatment can impact patients' abilities to use products, and likely impact response to therapies. Objective: This exploratory analysis examined the relationship between functional status and satisfaction with ability to use fentanyl pectin nasal spray (FPNS) for BTPc. Methods: Treatment satisfaction data were analyzed from a multicenter, open-label, long-term study using FPNS for managing BTPc in patients with Eastern Cooperative Oncology Group (ECOG) grade ≤ 2. Satisfaction with ease of use, convenience, and reliability of FPNS were assessed on three-question, four-point scales (1 = not satisfied, 2 = not satisfied or dissatisfied, 3 = satisfied, 4 = very satisfied) at the end of 1, 4, 8, and 12 weeks. For each domain, percentage of patients who reported being "satisfied or very satisfied" (score 3 or 4) with FPNS was analyzed based on ECOG grade. Results: Overall, > 90 % of patients with ECOG 0-2 reported being satisfied or very satisfied with FPNS across all three domains. Differences in patient satisfaction with FPNS by ECOG grade were clinically small though statistically significant (ease of use: p = 0.0022, convenience: p = 0.0057, and reliability: p = 0.0012). Conclusion: The FPNS device was well accepted irrespective of ECOG grade (0-2). Statistically, patients with higher performance status (lower ECOG grades) reported higher satisfaction scores, though effect size was small. Results imply the FPNS device provides a high level of usability irrespective of functional status, which is likely to promote use and thus likelihood of success in controlling BTPc.

Relationship between performance status and satisfaction with fentanyl pectin nasal spray