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Objective: To determine the efficacy of intra-articular knee infiltration with medical ozone in patients with chronic knee pain due to knee osteoarthritis. Methods: An observational, prospective and intrasubject, included 203 patients with knee osteoarthritis and pain secondary to most, there were a total of five intra-articular injections with medical ozone at a concentration of 25 ug / ml and a volume of 10 ml at weekly intervals. Analgesic quality was evaluated by visual analogue scale (VAS) and pain (WOMAC-A), stiffness (WOMAC-B) and functional capacity (WOMAC-C) using the questionnaire Western Ontario and McMaster Universities Osteoarthritis (WOMAC) before and after treatment. Results: 203 patients were performed a total of 305 procedures, 204 women and 101 men, with a mean age of 69.9 ± 9.4 years. Giving to EVA, WOMAC-A,-B and WOMAC WOMAC-C range of quantitative variables, the mean pre-treatment were 6.88 ± 2.30, 8.12 ± 3.76, 3.39 ± 1.88 and 29.15 ± 13.04, respectively, and the mean response after treatment, 3.98 ± 2.35, 4.61 ± 2.79, 2.10 ± 1.50 and 17.51 ± 10.36 respectively. The differences between the responses before and after treatment, compared with Student's t tests for paired data were all significant at p <0.001. Conclusion: The use of an intra-articular ozone concentration of 25 ug / ml and a volume of 10 ml is effective for the relief of chronic pain secondary to knee osteoarthritis. As most frequent complication was recorded mild pain during the administration of ozone, followed by feeling of occupation and joint crepitation so we can consider it also as a safe treatment free of systemic effects have required medical interventions. Key works: Arthritis knee. Pain. Infiltration. Ozone.

Tratamiento de la gonalgia por gonartrosis con ozono intrarticular