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Signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the loss of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion.

E-cadherina: expresión molecular en carcinomas de estómago de tipo difuso y tipo intestinal: Estudio realizado en Lima, Perú