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Background: There is a pressing need to identify environmental risk factors of dementia and depression in the elderly. Aims: To describe the methods and first results of the ZARADEMP Project, the first psychiatric study to document risk factors in incident cases of dementia (and depression) in a Southern European elderly population. Method: A three-wave (baseline and two follow-up waves) epidemiological study to identify incident cases of dementia (and depression) was completed in a representative sample population. Valid Spanish versions of case-finding instruments, including the Geriatric Mental State (GMS) were administered by standardized researchers. The incident cases, diagnosed by a panel of psychiatrists using DSM-IV criteria, will be included in a case-control study. Results: Response rate was acceptable (63.6% in Wave I, 87'2% in Wave II and 85'8% in Wave III), and 4,803 individuals completed Wave I. Diagnostic agreement was achieved in 91.4% of probable cases presented to the panel, and a total of 146 incident cases of dementia were identified. Conclusions: We feel confident that modem epidemiological requirements have been fulfilled and the statistical power in the calculations of risk will be acceptable.

the european journal of psychiatry

The ZARADEMP Project on the incidence, prevalence and risk factors of dementia (and depression) in the elderly community: II. Methods and first results