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espanolIntroduccion: El proposito de esta investigacion fue evaluar el efecto del humo del tabaco en la mucosa bucal in vivo usando un modelo animal. Materiales y metodos: La poblacion de estudio estuvo constituida por 20 ratas hembras Sprague Dawley, 10 expuestas al humo de 10 cigarrillos diarios por 16 semanas (GEC) y un grupo control no expuesto (GC). Las ratas fueron sacrificadas y se extrajo la lengua para su estudio histopatologico. Variables categoricas fueron comparadas mediante la prueba U de Mann-Whitney. Valores p Resultados: La mucosa lingual del GEC mostro mayores cambios epiteliales proliferativos que el GC, como hiperplasia basal (p= 0,001), acantosis (p= 0,0001), hipercromatismo y picnosis nuclear (p= 0,010 y 0,014 respectivamente), y displasia epitelial (p= 0,0001). En el corion de la mucosa del GEC se observo un incremento del infiltrado inflamatorio cronico (p= 0,007); y aunque no hubo aumento en el numero de vasos sanguineos en el GEC, es importante resaltar que la ubicacion de los mismos fue muy proxima al epitelio de revestimiento expuesto al tabaco. Discusion: El presente estudio, usando un modelo animal, demuestra que el humo del tabaco induce cambios precoces en la arquitectura tisular y morfologia de celulas epiteliales de la mucosa bucal de aspecto macroscopicamente sano. EnglishIntroduction: The purpose of this study was to evaluate the histopathological changes in oral tissues of rats exposed to tobacco smoke. Materials & methods: 20 female rats Sprague Dawley were included in the study and 10 rats exposed to environmental tobacco smoke of 10 cigarettes daily for 16 weeks. All animals were sacrificed and tissues extracted, died using H&E and finally evaluated under light microscope. Categorical variables were compared using U Mann-Whitney test. P values Results: Oral mucosa of rats exposed to tobacco showed augmented epithelial changes as basal hyperplasia basal (p= 0,001), acanthosis (p= 0,0001), nuclear hyperchromatism and picnosis (p= 0,010 y 0,014 respectively), and epithelial dysplasia (p= 0.0001). Increased chronic inflammatory infiltrate was also observed in this group (p= 0.007), as well as, a higher number of blood vessels although difference was not statistically significant. Discussion: Tobacco inhalation showed to produce tissue alterations of macroscopically healthy mucosa of rats. This study, using an animal model, demonstrated microscopical oral mucosa changes produced by tobacco smoke without clinical alterations.

Cambios histopatológicos de la mucosa bucal de ratas expuestas al humo de cigarrillos