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espanolLos trastornos vesiculobullosos subepiteliales representan desordenes autoinmunitarios que cogen origen de reacciones dirigidas hacia componentes de los hemidesmosomas o bien de las Zonas de la Membrana Basal (ZMB) de los epitelios escamosos estratificados. A estos trastornos ha sido conferido el termino de enfermedades ampollosa subepiteliales inmunomediadas (EASIM) y el penfigoide de las membranas mucosas (PMM) es el mas frecuente. Todas las enfermedades subepiteliales vesiculobullosas se presentan como lesiones ampollosas y descamativas, y el diagnostico debe de ser confirmado por una biopsia junta a tincion inmunologica. No hay un unico tratamiento capaz de controlar todas las enfermedades subepiteliales vesiculoampollosas; las diferencias inmunologicas entre las EASIM proporciona diferencias en las respuestas al tratamiento. Hoy en dia el tratamiento inmunorregulador es usado para controlar la lesion oral de PMM. EnglishSubepithelial vesiculobullous conditions are chronic autoimmune disorders that arise from reactions directed against components of the hemidesmosomes or basement membrane zones (BMZ) of stratified squamous epithelium to which the term immune-mediated subepithelial blistering diseases (IMSEBD) has been given. Mucous membrane pemphigoid (MMP) is the most common, but variants do exist. All subepithelial vesiculobullous disorders present as blisters and erosions, and diagnosis must be confirmed by biopsy examination with immunostaining, sometimes supplemented by other investigations. No single treatment reliably controls all subepithelial vesiculobullous disorders; the immunological differences within IMSEBD may account for differences in responses to treatment. Currently, as well as improving oral hygiene, immunomodulatory treatment is used to control the oral lesions of MMP, but it is not known if its specific subsets reliably respond to different agents.

Enfermedad de la mucosa oral: Penfigoide de las membranas mucosas