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In 1947, Ernst Chain moved from Oxford to Rome, hired as head of a new biochemistry department and of a penicillin production pilot plant in the Istituto Superiore di Sanità (Higher Health Institute). Here, he managed to make Rome one of the most important centres in the international network of antibiotic science. However, the development of the state-operated centre was not easy. Political and economic pressures, exerted both from home and abroad, posed many obstacles to the plan devised by Domenico Marotta, the general director of the Institute. The paper reconstructs Chain's venture in Rome, which lasted until 1964, while framing the history of the penicillin production plant in the context of diplomatic negotiations, national politics, and science policies.

A Chain is gonna come: Building a penicillin production plant in post-war Italy