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Purpose: Dioscorea du metorum (Pax) used in traditional medicine for the treatment of diabetes mellitus possesses hypoglycaemic effect. The present study investigates the effect of oral administration of the aqueous extract of the tuber on blood lipid and ketone levels in alloxan‐induced diabetic rats. Method: Wistar strain albino rats were made diabetic with the intraperitoneal administration of alloxan monohydrate. Consequently, an aqueous extract of Dioscorea dumetorum tuber was administered o rally to the d iabetic rats and their plasma and urine g lucose, t riacylglycerol, choles terol and â-hydroxybutyrate concentrations were estimated using standard procedures. Results were compared with un treated no rmal and diabetic c ontrol rats. Phytochemical screening of the extract of the tuber was also carried out. Results: Treatment with the e xtract significantly (p<0.05) r educed e levated b lood levels of triacylglycerol, cholesterol and β‐hydroxybutyrate a ssociated with a lloxan-induced d iabetes mellitus. The aqueou s extract t ested po sitive for flavonoids, alkaloids, saponins and cardiac glycosides. Conclusion: From this study, the tuber has proved not only to be an effective hypoglycaemic agent, but also po ssesses s ignificant (p<0.05) hypolipidaemic and hypocholesterolaemic properties while also ameliorating ketosis.

Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber