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Purpose: To investigate the phytochemical contents and genotoxic effects of Ficus carica and Schinus molle grown in healthy and polluted environments in Asir area, Saudi Arabia. Methods: Extracts of the aerial parts of the plants were screened for phytochemical constituents. Genotoxicity tests were carried out in mice using Comet assay, micronucleus test and chromosomal analysis. Results: Extracts of the two plants grown in polluted soil showed elevations in phytochemical and heavy metal contents, when compared with extracts from non-polluted sites. In genotoxicity tests, F. carica and S. molle extracts produced significant increases in the number of micro-nucleated cells in mice, compared to control. Cytotoxicity tests showed that extracts from plants grown in non-polluted environments did not decrease polychromatic erythrocytes (PCE) to normochromatic erythrocytes (NCE) ratio in bone marrow cells, relative to control. Mice in the vehicle control group showed some aberrant metaphases and a few aberrations per hundred metaphases. Conclusion: Pollution has significant effects on phenolic compounds, total flavonoids, and genotoxic potential of the two plants. Keywords:  Ficus carica , Schinus molle , Pollution, Genotoxicity, Total phenolic compounds, Total flavonoids

tropical journal of pharmaceutical research

Comparative studies on the effect of environmental pollution on secondary metabolite contents and genotoxicity of two plants in Asir area, Saudi Arabia